Research Core Resources

PKD Research Biomaterials and Cellular Models Core

Director: Darren P. Wallace, PhD

Supported by the PKD Foundation

The PKD Research Biomaterials and Cellular Models Core at the University of Kansas Medical Center has a new website ( This Core is a resource for human PKD materials, including fixed and frozen tissues, cyst fluids and primary cells isolated from cysts of human PKD kidneys. The Core also generates biological materials from animal models of PKD and can assist investigators on in vitro models of PKD.

The website has information for investigators about biomaterials available through the Core, as well as information for PKD patients on how to arrange to have their cystic kidneys donated for research with the assistance of the PKD Foundation.

For more information, contact Darren Wallace, Ph.D., Core Director, by telephone (913-588-3889) or email (

ADPKD Mutation Database

Peter Harris, Ph.D., Database Director

Supported by the PKD Foundation

The Autosomal Dominant Polycystic Kidney Disease (ADPKD) Database (PKDB) was established to facilitate the characterization of ADPKD variants in PKD1 and PKD2, the two genes known to have mutations causative of ADPKD.  After the March 2014 launch of version 3.0, the PKDB now contains data from 3 new studies, increasing the number of total variant entries to 2595, and the number of mutations to 1469.  In terms of the total number of affected families, the Database now contains 2292 entries, an overall increase of 74%.  Mutations in the HALT cohort will become available in the next year, adding information from another ~840 families to the Database.

More information about the PKDB

Electron Microscopy Core

Bob Bacallao, M.D., Director

Supported by the PKD Foundation

The Electron Microscopy Core for PKD Research utilizes the Electron Microscopy Center of Indiana University School of Medicine, under the direction of Dr. Bob Bacallao. This core is dedicated to facilitate research on polycystic kidney disease and other hepatorenal fibrocystic diseases and is well equipped to handle most electron microscopy needs. Services are provided at a significant discount because the costs are underwritten by the PKD Foundation.

More information about the Electron Microscopy Core for PKD Research
Research project application form (DOC)

Baltimore PKD Core Center

Center Director: Terry Watnick, M.D.
Center Co-Director: William Guggino, Ph.D.
Center Administrator: Karleen Schuhart

Supported by NIDDK and the University of Maryland School of Medicine

The Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center is founded on a tradition of innovative PKD research at our Center. The goal of the Center is to promote translational PKD research by providing unique resources and expertise to an international group of investigators.

Biomedical Cores

  • Core B: Antibody Validation and Vectorology Core
  • Core C: Mouse Models and Biobank
  • Core D: Cell Culture and Engineering
  • Core E: Clinical and Translational Core Resource

Educational Programs

The Center offers educational enrichment programs that strive to encourage critical thought which will yield creative approaches to research questions related to cystic kidney diseases.

Pilot and Feasibility Program

The Pilot and Feasibility Program can support up to three new projects per year. In selecting projects preference is given to innovative lines of inquiry, junior investigators, and new investigators in the PKD field.

Join our Research Base

To become a member of our research base, contact Center Administrator, Karleen Schuhart to submit biosketch.

More information about the Baltimore PKD Core Center

Mayo Translational PKD Center

Director: Vincent E. Torres, M.D., Ph.D.

Supported by NIDDK

The Mayo Translational PKD Center focuses on translating basic science research findings into new and better treatments that imporve the care of patients with PKD.

More information about the Mayo Translational PKD Center

Molecular Genetics and Proteomics

Director: Peter C. Harris, Ph.D.

Provides specialized services in support of research and clinical trials related to autosomal dominant polycystic kidney disease (ADPKD) to investigators worldwide. These services include:

  • Mutation screening of large typical ADPKD populations
  • Mutation screening of cell lines derived from ADPKD patients
  • Genetic Screening of atypical PKD families
  • Urine collection and fractionation

Molecular Genetics and Proteomics overview

Model Systems

Director: Miahael F. Romero,, Ph.D.

Develops and makes available PKD model systems and technologies, which are used to evaluate potential therapies and determine the function of PKD proteins. These include:

  • C. elegans PKD-targeted services
  • Rodent PKD-targeted services
  • Zebrafish PKD-targeted Services

Model Systems overview

Human Imaging

Director: Bernard F. King, M.D.

Provides two imaging services to assess and catalog PKD progression or regression.

Imagain data management: Facilitates the transmission, collection and storage of anonymized imaging data used in translational PKD research, and provides a system that enables PKD researchers around the United States to exchange images.

Image Analysis: of semi-automatic magnetic resonance (MR) and computed tomography (CT) image and volumetric analyses of polycystic kidneys and liver, as well as functional assessment of the kidney and heart (including measurements fo renal blood flow).

Human Imaging overview

UAB Hepato/Renal Fibrocystic Disease Core Centers

Director: Bradley K. Yoder, Ph.D.

More information about the UAB Recessive Kidney Disease Core Centers

Core A: ARPKD Clinical and Genetic Resource

Director: Lisa M. Guay-Woodford, M.D.
Co-Director: Ludwine Messiaen, Ph.D. (Director, UAB Medical Genomics Lab)

More information about the Core A; ARPKD Clinical and Genetic Resource

Core B: Engineered Mouse Resource

Director: Bradley K. Yoder, Ph.D.
Co-Director: Robert A. Kesterson, Ph.D. (Director, UAB ESC/Transgenic Core)

More information about the Core B: Engineered Mouse Resource

Core C: Cellular Physiology Resource

Director: P. Darwin Bell, Ph.D.
Co-Director: Erik M. Schwiebert, Ph.D.

More information about the Core C: Cellular Physiology Resource

Core D: Tissue Characterization and Immunoreagent Resource

Director: Joanne Murphy-Ullrich, Ph.D.
Co-Directors: Gene Siegal and Mary Ann Accavitti-Loper

More information about Core D: Tissue Characterization and Immunoreagent Resource

Center for Polycystic Kidney Disease Research at Yale

Director: Stefan Somlo, M.D.

The Center for Polycystic Kidney Disease Research at Yale was established with the overarching goal to facilitate basic and translational research that will advance the understanding, prevention and treatment of polycystic kidney diseases.

  • Supported by NIDDK

Biomedical Research Cores

  • Animal Models and Preclinical Screening Core
  • Translational and Analytical Core
  • Functional Cell Biology Core

Pilot and Feasibility Grant Program

Educational Enrichment Program

More information available at:

National Disease Research Interchange (NDRI)

Supported by NIH

For 28 years NDRI has been a major source of human biomaterials for approved research studies, providing scientists with high quality customized biomaterials for use in studies to understand human disease.  Funded by NIH, NDRI is a not-for-profit organization that places around 20,000 normal and diseased tissues each year with researchers in academia and the biomedical and pharmaceutical industries.

More information about NDRI or call 800-222-NDRI (6374).

National Stem Cell Foundation

The National Stem Cell Foundation is a not-for-profit organization that funds clinical trials and research and currently focuses on stem cell kidney transplants, sickle cell disease and rare metabolic disorders.  They just launched their new website which features information about kidney disease and transplants.

More information about the National Stem Cell Foundation

Knockout Mouse Project

Supported by NIH

NIH has provided funding to establish and support a repository for its Knockout Mouse Project (KOMP). This is part of a $50 million trans-NIH initiative to increase the availability of genetically-altered mice and related materials. The University of California, Davis (UC Davis) and Children’s Hospital Oakland Research Institute (CHORI) in Oakland, California, will collaborate to preserve, protect and make about 8,500 types of knockout mice and related products available to the research community.

More information about the KOMP resources

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©2020, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.

©2020, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.